In the summer of 1649, the village of Penston in the parish of Pencaitland, Haddington, became the setting for a series of legal actions that would draw Issobell Murray into the machinery of the Scottish witch trials. A married woman of middling status, Issobell first appeared in the judicial records on 8 June 1649, when she was denounced by Margaret Dicksone. This initial accusation served as a catalyst for a wider investigation, as the social networks of the village were scrutinized; Issobell was subsequently named as an accomplice by several other individuals, including Barbara Purdie, Helen Lausone, Margaret Bartilman, and Margaret Hog.
By 2 July 1649, formal charges were brought against her, centering on her alleged involvement in a witches' meeting. Following her arrest, the legal process concluded with a recorded confession on 8 September 1649. Throughout the proceedings, Issobell’s own testimony further expanded the scope of the inquiry, as she named nine other individuals—eight women and one man—as participants. In addition to those who named her, she was also identified as a figure of concern by Grissell Anderson and John Dicksone, reflecting the interconnected nature of the accusations that defined this period of intense judicial activity. While specific details regarding her final trial remain absent from the surviving records, the documentation captures a brief but significant moment in the social and legal history of 17th-century East Lothian.